First of all I want to wish you Happy Pharmacy week in advance.
Supercritical fluid is defined as a substance at a temperature and pressure above its critical point where the liquid and gas phases do not exist. (1)
Critical point: The point of highest temperature and pressure at which the substance can exist as gas and liquid in equilibrium. (2) It can diffuse through solids like gases and dissolves materials like liquids. (1)
Supercritical fluid chromatography is a chromatographic technique that uses supercritical fluids as the mobile phase It has few advantages over gas chromagraphy that is gas chromatography is suitable only for volatile solvents as mobile phase.
Solubility with the capability to use nonselect gas phase detector is the major advantage of supercritical fluid chromatography(SFC).
Glass is one of the old and cheapest materials using for the packing of various types of pharmaceutical formuations, especially for the parenteral formulations. It has been used for over 6000 years. Containers for parenteral formulations are made are made as far as possible from the materials that are sufficiently transparent and to permit the visual inspection of the contents.
Hai friends, Sorry for the delay .The reason for the delay is because we were having exams.
THEORY OF DRYING
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It is defined as the process of removal of small quantities of liquid from a material by the application of heat.
PHARMACEUTICAL APPLICATIONS OF DRYING –
When gas is introduced from the bottom of bed of solid particles, the gas moves upwards and move through the spaces between the solid particles. If the velocity of gas is low then the aerodynamic drag on the particles is also low and the solid bed will be in a fixed state.
Dear readers I am back again and I do apology about my late posting due to my busy timetable in the lab. This time we will
TAMARIND SEED POLYSACCHARIDE:-COLON SPECIFIC PROPERTIES
Tamarind seed polysaccharide (TSP) is a biodegradable polysaccharide extracted from Tamarind seeds (Tamarandus indica Linn. Family; Leguminosae) called as TSP has been found to have a wide application in pharmaceutical industry1.
This is a guidance document that comes under Chemistry manufacturing and controls section of USFDA. During formulation development, initially, development process is carried out in small batch sizes generally in the multiples of 10X i.e., small scale or lab scale. The batch size is then increased to multiples of 100X i.e., medium scale or pilot scale. In production scale or large scale, manufacturing is carried out in large numbers usually multiples of 1000X depending upon the requirement.
This guideline suggests looking into the quality of drug product during development stage itself. It says that Quality should be built into the product design rather than testing into products1 during the initial stages of development, all the variables that may likely effect the production or manufacturing process should be completely studied. Those critical variables that are found to be affecting the quality of product must be properly controlled and monitored during the process.
Orally disintegrating tablets also called as fast dissolving or mouth dissolving tablets are such kind of dosage forms which when placed in mouth disintegrates rapidly in a matter of seconds(1). They are different from lozenges or buccal tablets which require more than a minute to get dissolved in mouth(1). Any dosage form or a novel drug delivery system which improves patient compliance is of great interest to scientists in which orally disintegrating tablets stands first among them.