TAMARIND SEED POLYSACCHARIDE:-COLON SPECIFIC PROPERTIES
Tamarind seed polysaccharide (TSP) is a biodegradable polysaccharide extracted from Tamarind seeds (Tamarandus indica Linn. Family; Leguminosae) called as TSP has been found to have a wide application in pharmaceutical industry1.
Syrups consists of sugar in water. These are highly concentrated, obviously viscous preparations. And they may or may not contain therapeutic agent.
In simple syrup sucrose at the concentration of 85% is dissolved in water. These are sometimes used as a coating on to the surface of the tablets.
If some therapeutic agent is present, then it is called as medicated syrup.
Dose dumping is defined as "Unintended, rapid drug release in a short period of time of the entire amount or a significant fraction of the drug contained in a modified release dosage form1." A sustained/extended/controlled release dosage form is intended to release the drug in desired concentrations for a prolonged period of time. A dosage form is said to be dose dumped when there is an excess release of drug at a particular time interval other than the stated or required amount. This results in higher systemic drug concentrations that may result in toxicity.
This guideline suggests looking into the quality of drug product during development stage itself. It says that Quality should be built into the product design rather than testing into products1 during the initial stages of development, all the variables that may likely effect the production or manufacturing process should be completely studied. Those critical variables that are found to be affecting the quality of product must be properly controlled and monitored during the process.
Orally disintegrating tablets also called as fast dissolving or mouth dissolving tablets are such kind of dosage forms which when placed in mouth disintegrates rapidly in a matter of seconds(1). They are different from lozenges or buccal tablets which require more than a minute to get dissolved in mouth(1). Any dosage form or a novel drug delivery system which improves patient compliance is of great interest to scientists in which orally disintegrating tablets stands first among them.