Evaluation of In-Vivo wound healing activity of Anthocephalus cadamba leaf extract on different wound model

umachigisanjay's picture
Submitted by Sanjay. P Umachigi on Thu, 01/08/2009 - 11:35.

Publication Type:

Conference Paper

Authors:

Sanjay P Umachigi; Jayaveera K. N; C.K. Ashok Kumar; G.S.Kumar,

Source:

Society for Economic Botany, Durham, North Carolina (2008)

URL:

www.econbot.org/_organization_/07_annual_meetings/meetings_by_year/2008/SEB2008_Scientific_Program_withabstracts.pdf

Keywords:

Wound healing; Nitrofurazone; Ointment;

Abstract:

Introduction
Anthocephalus cadamba (Roxb.) Miq. Syn A. chinensis (Lamk) A. Rich (Rubiaceae) is widely distributed throughout the greater part of India and is used as a folk medicine in the treatment of fever, anemia, uterine complaints, blood
diseases, skin diseases. leprosy, dysentery as antidiuretic, and for improvement of semen quality, leaves is recommended as a gargle in cases of stomatitis. The major constituents of bark are triterpenes, tripernoid glycosides, saponins, indole
alkaloids cadambine, 3a-dihydrocadambine, cadamine, isocadamine and isodihydrocadambine
Objectives
The aim of the present study was to investigate the in-vivo wound healing activity of Anthocephalus cadamba leaf extract on different wound models in rats
Methods
The methanol extract of Anthocephalus cadamba leaves were investigated for the evaluation of their wound healing potential on different experimental models of wounds in rats. The methanol extract of leaves in the form of an ointment with two different concentrations (5% and 10% w/w ointment of leaf extract in simple ointment base) was evaluated for wound healing potential in an excision wound model and an incision wound model in rats.