sajid_hk

Introduction-

Proteus sp., especially Proteus mirabilis, holds urinary Tract Infection as its most common manifestation of disease. It’s a gram-negative bacteria.

Determinants of Pathogenicity-

1) Endotoxin-
The Lipid A component of bacterial LPS (Lipopolysaccharide) is pyrogenic and serves as an endotoxin and causes pyretic effect by causing fever in UTI (Urinary Tract Infections).

2) Urease-

Urease, produced by P.mirabilis serves to convert urea into ammonia and neutralizes the acidity of urine and produce conditions favourable for growth of bacteria in lower urinary tract.