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Lack of Dissolution protocols for selected dosage forms in USP 21 / NF 19

pratyesh's picture
Submitted by pratyesh on Mon, 03/31/2008 - 12:11.
in
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In the United State of Pharmacopoeia (USP); many of the drug formulations do not have any standard dissolution apparatus for the standardization. So many times manufactures get a chance to supply less drug quantity which is generally stated on the container.


Few of the dosage form are discussed here.

1. Dissolution of the topical dosage forms

Drug releases studies from gels, creams and ointments are found in same criteria. Study of the dosage form required during its development phase and as a routine quality control test for assuring uniformity of the finished products. Such studies provide helpful information about physiological parameters involved in the invivo pre-cutaneous absorption such as diffusion coefficient and the stability of drug in the specific vehicle required.

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