Particle-Size Distribution II: The Problem of Sampling Powdered Solids

Harry G. Brittain
Pharmaceutical Technology JULY 2002 he first article of this series outlined some of the general precepts of particle size and shape (1). o­ne might have thought it appropriate to move into discussions of some of the most important experimental methods used to deduce that type of information, but those topics cannot be addressed until the procedure for obtaining a proper sample for analysis is discussed (2,3). Although o­ne may use extraordinary care and technical skill while performing a given method for the deduction of the particle-size distribution of a powdered solid, the results will have absolutely no value unless the sample used for the analysis is indicative of the bulk from which it was taken. Nowhere else is the phrase “garbage in, garbage out” more appropriate.

For full article Click Here