Synthesis & antimicrobial activity of 7-chloro-6-fluoro-N- [(1E)-(4-substituted phenyl) methylidene]-1,3-benzathiazole-2-amine

Vikash Kumar's picture
Submitted by Mr. Vikash Kumar on Thu, 08/21/2008 - 10:08.

Publication Type:

Journal Article

Authors:

Ved Parkash Yadav; S. N. Pandeya; U. K. Singh; Vikash Kumar; Amit Kukshal

Source:

INDIAN DRUGS, Volume 45(8), Issue August, p.655-658 (2008)

Keywords:

Benzothiazole; synthesis; antibacterial activity.

Abstract:

7-Chloro-6-fluoro-N-[(1E)-(4-substitutedphenyl) methylidene]-1, 3-benzothiazole -2-amine (4a-f) have been synthesized by the cyclization of 3-chloro-4-fluoroaniline (1) with potassium thiocyanate and bromine to give 7-chloro-6-fluoro-2-aminobenzothiaz ole (2) followed by treatment with aromatic aldehyde (3a-f) in presence of alcohol. The title compounds & their derivatives have been characterized by their spectral data. The synthesized compounds screened for their antibacterial activity against Gram negative and gram positive such as Escherichia coli MTCC 1687 & Staphylococcus aureus MTCC 737.