Vol. 8 Issue 2
Multiparticulate drug delivery systems consist of large number of discrete units, each exhibiting desirable characteristics. They are especially suitable for achieving controlled or delayed release of the drug with lower risk of dose dumping. Various techniques like spheroidal oral drug absorption system (SODAS), programmable oral drug absorption system, pelletized delivery system, and pelletized tablet system were developed for oral delivery of multiparticulates. Pelletized tablet consists of polymer coated drug pellet compressed into a tablet.
The need for delivering drugs to patients efficiently with minimum side effects has prompted pharmaceutical industries to be engaged in development of new drug delivery systems. Pediatric and geriatric patients find it difficult to swallow solid dosage forms like tablets. Mouth dissolving tablet that dissolve or disintegrate rapidly in oral cavity result in solution, is an ultimate remedy for this problem. In addition they give pleasing mouth feeling. MDT has advantages such as patient compliance, quick onset of action, improved bioavailability, etc.
Proniosomal gel is nonionic surfactant based vesicle system which exists in different liquid crystalline phases. Mixing of the surfactant in an alcohol and limited hydration with aqueous phase leads to the formation of proniosomal gel. Due to the limited amount of water present, these systems behave as viscous phases. The various phases of liquid crystalline structures can be utilized as such for topical/transdermal applications or can be used after further hydration to form niosomes.
Decisions to approve, prescribe and consume medicines involve risk/benefit assessments by regulatory agencies, health care professionals and consumers. For serious or life threatening conditions, drugs with higher risks for adverse effects or for serious adverse effects are sometimes acceptable. For example, some life-saving cancer chemotherapies are known human carcinogens. However, if one is suffering from a life threatening tumor, a 5% risk of a secondary, treatment-related tumor is generally considered acceptable.
By definition, colonic delivery refers to targeted delivery of drugs into the lower GI tract, which occurs primarily in the large intestine (i.e. colon). Targeted drug delivery to the colon would therefore ensure direct treatment at the disease site, lower dosing and fewer systemic side effects. In addition to local therapy, the colon can also be utilized as a portal for the entry of drugs into the systemic circulation.
Objective of this article is to highlight the scope of career opportunity for the pharmacy professional in Pharmaceutical Industry. Although job avenues for pharmaceutical professionals are with pharmaceutical industry, government departments, universities, teaching, hospitals, investigation and research institute etc, present discussions is restricted mainly to point out the career opportunity of pharmaceutical professionals in Industry. At the outset the article depicts the portrait of vast and growing industry pharmaceutical industry.